PROSITE is complemented by Pro Rule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].
To paraphrase Orwell, in Animal Farm, we can say that "some regions of a protein sequence are more equal than others" ! Lesk: "There are many short sequences that are often (but not always) diagnostics of certain binding properties or active sites.In some cases the sequence of an unknown protein is too distantly related to any protein of known structure to detect its resemblance by overall sequence alignment, but it can be identified by the occurrence in its sequence of a particular cluster of residue types which is variously known as a pattern, motif, signature, or fingerprint.These motifs arise because of particular requirements on the structure of specific region(s) of a protein which may be important, for example, for their binding properties or for their enzymatic activity.For information about the licensing scheme see the prosite license or send an email to Prosite License.The above copyright notice also applies to this user manual as well as to any other PROSITE document.
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In other words it must exhibit both high sensitivity and high specificity.A number of the patterns described in this dictionary have been published.In this section we will explain how we selected or developed the signature patterns described in this compilation.Our first and most important criterion is that a good signature pattern must be as short as possible, should detect all or most of the sequences it is designed to describe and should not give too many false positive results.If you find errors, omissions, or if you want to suggest new sites, patterns or profiles to be added to this database, please let us know.
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You can contact us (by electronic mail preferably) at prosite.expasy.org/contact.
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Currently, most of the new PROSITE entries are centered around profiles and are developed by the PROSITE collaborators at the SIB Swiss Institute of Bioinformatics in Geneva and Lausanne.
PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them [More...].